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Our focus is accuracy in image analysis , as this is the most important determinant of statistical power in clinical trials. We accomplish this by integrating unparalleled excellence in image reading with meticulous quality control and experienced multi-site protocol design.

Spire Sciences Reading System

Designed by radiologists for radiologists, Spire Science’s reading processes and systems are more closely aligned with how radiologists approach image analysis,enabling more accurate and timely reading results than those of other core labs. Our reading workstation is the product of 30 years experience developing and implementing the highest performing systems for clinical trials.

Based on direct experience reading centrally for other imaging core labs, we know firsthand from the radiologist-user perspective how other reading systems operate, and we understand how reader fatigue, distraction and frustration can contribute to human error, and most importantly, our reading process and system mitigate those problems.

Spire Sciences Reading System

Spire's smart reading system selects, arranges and optimally displays images from multiple visits with consistent windowing, leveling, sizing, centering and anatomical slice location, according to the reader's individual needs and preferences, and does so almost instantly, virtually eliminating the most time and energy consuming step in the image reading process. This allows expert readers to focus on interpretation and measurement, which are the ultimate deliverables of any reading.

All other steps in the reading process not related directly to image analysis have either been eliminated or minimized, resulting in reading throughput speeds as much as 10-fold faster than those of others. Spire's reading system thus enables the most accurate, error-free and timely readings in the industry both for in-house radiologists at Spire Sciences and sponsor-selected readers operating remotely.

Schedule an appointment with us, so we can show you how Spire Sciences delivers the most accurate and timely image analyses in the industry.


Expert Radiologists

Spire Sciences' radiologists are specialists in Clinical Trial Imaging and deliver reading accuracy and throughput speeds that are unparalleled in the industry. Our radiologists have been trained at the world’s top-ranked universities, many holding senior leadership positions at these and other institutions. They have decades of experience reading for clinical trials – in some areas, more experience than anyone else in the world. Furthermore, at Spire, readers routinely undergo end-of-study discrepancy reviews in order to improve reading accuracy and inter-reader agreement. This focus on quality control and continuous reviewer training underscores our commitment to excellence and accuracy.

Spire Sciences Reading System

Image Acquisition Training & Central Quality Control

No matter how experienced and dedicated the expert radiologist may be, or how sophisticated and enabling the reading system they use is, readings can be only as accurate as the quality of the images is able to support. High-quality images in turn depend on proper image acquisition training and central quality control by experts whom site technologists trust and understand. This is especially challenging these days, as worldwide shortages in imaging technologists place greater stress on imaging facilities that support clinical research.

Our experts have trained hundreds of facilities around the world for decades, and we know what it takes to get outstanding results even in the face of these growing challenges.


Imaging Protocol Design

Imaging protocols for clinical trials must allow multiple sites from different countries, with different equipment and different internal processes, who have never worked with each other, to acquire images that can nevertheless be pooled and reviewed without significant technical or quality differences among them. Doing this properly is extremely difficult and requires special technical expertise and experience.

Mounting resource limitations at imaging facilities around the world complicate this further and make it more important than ever that research protocols deviate as little as possible from local clinical routines and not disrupt clinical workflows.

Spire Sciences' experts have designed hundreds of imaging protocols for clinical trials across a range of therapeutic indications, and have the scientific, technological and regulatory knowledge and practical hands-on experience needed to turn the scientific needs of a study into practical reality.